Abstract: The microstructure, hardness, wear resistance of cladding layer, which Fe-Cr-B-Si-Mo alloy powders were clad by using laser multi-layer on the 1045 steel substrate, were researched with scanning electron microscope, optical microscopy, micro-hardness tester and wear testing machine. The results show that the microstructure of the layer is fully dense with rapidly solidified microstructure. There is a metallurgical bonding between layer and layer, so no weakness in the whole material in theory. The hardness of the laser is about 760-780 HV. The wear resistance of laser cladding coatings is 21.7 times higher than that of the unclad 45 steel. Laser cladding layer has higher metallurgy quality and wear resistance.