Abstract: In order to solve the problem of poor mechanical properties of joint caused by intermetallic compounds in the welding seam of titanium/steel, according to the high entropy technology of weld metal, the multi-component Ti₁₀Fe₂₉Ni₃₂Cu₂₂V₇ alloy with good plasticity and toughness was designed and prepared according to the first principles of thermodynamics based on density functional theory, which was used for TIG welding of TA2/0Cr18Ni9 sheet. The results show that: using Ti₁₀Fe₂₉Ni₃₂Cu₂₂V₇ welding material for fusion welding titanium/steel, the welding joint morphology is complete, no obvious welding defects, and the bonding between weld metal and base metal is good. The microstructure of the weld center is composed of equiaxed grains, and the microstructure of the fusion zone is characterized by columnar crystals. These crystals have a simple cubic solid solution structure, which effectively avoids the formation of intermetallic compounds. The tensile strength of the joint is high, up to 205 MPa.