Abstract: Welding research of 6005A-T6 aluminum alloy profile for high-speed train was done by using tandem MIG welding and laser-tandem MIG hybrid welding individually.The weld appearance, welding distortion, mechanical properties of the joints and microstructure were analyzed.The results demonstrated that high-efficient welding for the profile was achieved by using laser-tandem MIG hybrid welding, the speed of which was up to 4.5 m/min.The process had a good gap bridging ability that even if the gap of the butt joint was up to 1.4 mm, a good weld appearance could also be got.While the hybrid welding speed was greater than 4 m/min, the welding distortion of the laser-tandem MIG hybrid joints was just about 40% of that of the tandem MIG joints.And tensile strength of the hybrid joints was 83% of that of 6005A-T6 base metal, 9% higher than that of the tandem MIG joints.