Abstract: Misalignment is an important quality evaluation standard in tailor welded blanks.The control of misalignment, especially for thinner blanks, is a difficult problem in tailored blank laser welding process.The production and control of misalignment is studied based on a tailored blank laser welding system.The influential factors of the misalignment are obtained after numbers of experiments: the deformation of the blanks before welding, the intensity of the clamping force, the uniformity of the clamping force, deformation of the clamping beam, flatness error of the based platform and the welding process.A mathematical model is established according to the analysis of misalignment.Experimental results indicate that the model provides an effective theorical guidance in improving welding quality.