Abstract: TA2/316L joints acquired by explosive welding were treated by hot isostatic pressing treatment at the pressure of 150 MPa and at 850℃ for 2 hours.The effects of the treatment on the shear strengths, microstructure and chemical composition distribution of the joints were investigated.The treatment made the defects in the joints heal and inter-diffusion space of Ti, Cr, Fe and Ni be longer and also the embrittlement phases increase.The treated samples breaks along embrittlement phase during shear tests, which is different from the samples before treatment, and it generally fails at TA2 alloy sides of the joints.