Abstract: This paper concentrates on the welding performance of GTi70 and TC4 dissimilar materials. The microstructure and mechanical properties of the welded joint with laser welding were investigated, which shows the weld ability of GTi70 and TC4.The micro structures and fracture morphologies of the welded joint were analyzed through OM, XRD and SEM, and the detailed analysis of tensile strength were performed. The results demonstrated that the tensile strength of welding joints were higher than GTi70 at room temperature, while the tensile strength was higher than TC4 at 500, 600 and 750 °C. The tensile fracture and shear fracture of welded joint were plastic fractures. In addition, compared to continuous laser welding seam, the micro structure and mechanical properties of pulsed laser welding seam were better.